Author/Authors :
Mohd Mustapa، نويسنده , , M.Firouz and Harris، نويسنده , , Richard F Mould، نويسنده , , Jessica and Chubb، نويسنده , , Nathan A.L. and Schultz، نويسنده , , Darren and Driscoll، نويسنده , , Paul C. and Tabor، نويسنده , , Alethea B. Tabor، نويسنده ,
Abstract :
We report a new approach to the on-resin synthesis of cyclic peptides containing unnatural thioether side-chain bridges. An orthogonally protected nor-lanthionine was incorporated in a linear precursor peptide via stepwise solid-phase synthesis. This was followed by double allyl deprotection, cyclisation using PyAOP and subsequent chain-extension to give an analogue of ring C of nisin.
