Title of article
Reactivity switching on solid support: solid-phase synthesis of tertiary amines by reduction of tertiary amides with LiAlH4
Author/Authors
Akamatsu، نويسنده , , Hisashi and Kusumoto، نويسنده , , Shoichi and Fukase، نويسنده , , Koichi، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2002
Pages
3
From page
8867
To page
8869
Abstract
Reactivity of LiAlH4 was controlled by using solid-phase reaction conditions. Tertiary amides bound to gel-type polystyrene support were reduced with LiAlH4 to give tertiary amines with satisfactory purity, whereas the reduction of similar tertiary amides in solution gave secondary amines as main products. Solid-phase synthesis of tertiary amine libraries was achieved by using this method.
Keywords
Reduction , Amines , solid-phase synthesis , Combinatorial chemistry , Amides
Journal title
Tetrahedron Letters
Serial Year
2002
Journal title
Tetrahedron Letters
Record number
1659317
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