Title of article
Optional ortho and lateral lithiations of 4,4-dimethyl-2-(o-tolyl)oxazolines
Author/Authors
Tahara، نويسنده , , Naruki and Fukuda، نويسنده , , Tsutomu and Iwao، نويسنده , , Masatomo، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2002
Pages
4
From page
9069
To page
9072
Abstract
4,4-Dimethyl-2-(o-tolyl)oxazolines 1 undergo normal lateral lithiation at the benzylic position by treatment with sec-BuLi in diethyl ether at −78°C. In contrast, metalation of 1 with sec-BuLi/TMEDA in diethyl ether at the same temperature leads to ortho-lithiation at the 6′-position. Rationalization for the unusual ortho-lithiation of 1 is proposed.
Journal title
Tetrahedron Letters
Serial Year
2002
Journal title
Tetrahedron Letters
Record number
1659437
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