Title of article
Bisubstrate-type inhibitor of sialyltransferases
Author/Authors
Hinou، نويسنده , , Hiroshi and Sun، نويسنده , , Xue-Long and Ito، نويسنده , , Yukishige، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2002
Pages
4
From page
9147
To page
9150
Abstract
A convergent strategy for the construction of bisubstrate-type sialyltransferase inhibitor (1) was developed. It consists of consecutive coupling of three components (N-acetyllactosamine, sialic acid, and CMP), followed by oxidation and deprotection. As expected, compound 1 showed potent inhibitory activities toward both 2,3-(N)- and 2,6-(N)-sialyltransferase.
Keywords
bisubstrate , Inhibitor , Sialyltransferase
Journal title
Tetrahedron Letters
Serial Year
2002
Journal title
Tetrahedron Letters
Record number
1659485
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