Title of article
Design and synthesis of tubulin ligands based on epothilones: a preliminary study
Author/Authors
Vielle، نويسنده , , Sophie and Raimbaud، نويسنده , , Eric and Bertrand، نويسنده , , Philippe and Quintard، نويسنده , , Delphine and Renard، نويسنده , , Pierre and Pfeiffer، نويسنده , , Bruno and Gesson، نويسنده , , Jean-Pierre، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2002
Pages
4
From page
9213
To page
9216
Abstract
Starting from the X-ray structure of epothilone B, an original, non macrocyclic, structure has been designed to mimic the key structural features of this potent anticancer agent; the preparation of a key intermediate incorporating four stereogenic centers is described from cyclohexane-1,3-dione.
Journal title
Tetrahedron Letters
Serial Year
2002
Journal title
Tetrahedron Letters
Record number
1659526
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