Title of article :
Spirocyclization strategy toward indole phytoalexins. The first synthesis of (±)-1-methoxyspirobrassinin, (±)-1-methoxyspirobrassinol, and (±)-1-methoxyspirobrassinol methyl ether
Author/Authors :
Kutschy، نويسنده , , Peter and Such?، نويسنده , , Mojm??r and Monde، نويسنده , , Kenji and Harada، نويسنده , , Nobuyuki and Maru?kov?، نويسنده , , Renata and ?urillov?، نويسنده , , Zuzana and Dzurilla، نويسنده , , Milan and Miklo?ov?، نويسنده , , Mariana and Mezencev، نويسنده , , Roman and Moj?i?، نويسنده , , J?n، نويسنده ,
Abstract :
The first syntheses of cruciferous indole phytoalexins (±)-1-methoxyspirobrassinin, (±)-1-methoxyspirobrassinol, (±)-1-methoxyspirobrassinol methyl ether as well as a new syntheses of phytoalexins (±)-spirobrassinin and cyclobrassinin were achieved by dioxane dibromide (DDB)-mediated spirocyclization of brassinin and its 1-substituted derivatives.
Keywords :
Phytoalexins , indoles , dioxane dibromide , spirocyclization , Antitumor activity
