Highly sensitive and selective spectrofluorimetric determination of metoclopramide hydrochloride in pharmaceutical tablets and serum samples using Eu3+ ion doped in sol–gel matrix

A simple, sensitive and selective spectrofluorimetric method for the determination of Metoclopramide hydrochloride (MCP) is developed. The MCP can remarkably enhances the luminescence intensity of the Eu3+ ion doped in sol–gel matrix at λex = 380 nm in DMSO at pH 8.7. The intensity of the emission band of Eu3+ ion doped in sol–gel matrix increases due to energy transfer from MCP to Eu3+ in the excited state. The enhancement of the emission band of Eu3+ ion doped in sol–gel matrix at 617 nm was found to be directly proportional to the concentration of MCP with a dynamic range of 5 × 10−9 − 1.0 × 10−6 mol L−1 and detection limit of 2.2 × 10−11 mol L−1.