Title of article
Improved large-scale synthesis of phenylisoserine and the taxol C-13 side chain
Author/Authors
Voronkov، نويسنده , , Michael V and Gontcharov، نويسنده , , Alexander S. S. Wang، نويسنده , , Zhi-Min، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2003
Pages
3
From page
407
To page
409
Abstract
Dihydrodihydroxycinnamic acids and their esters react with acetonitrile or benzonitrile in the presence of sulfuric acid to afford the corresponding syn-β-amino-α-hydroxypropionic acid derivatives. High yields and diastereoselectivity of this transformation allows preparation of various phenylisoserine derivatives on a practical scale.
Journal title
Tetrahedron Letters
Serial Year
2003
Journal title
Tetrahedron Letters
Record number
1660051
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