Title of article :
First synthesis of 2-[alkylamino(diethoxyphosphoryl)methyl]acrylic ethyl esters
Author/Authors :
Kra??em، نويسنده , , Houda and Abdullah، نويسنده , , Meysun Ibrahim and Amri، نويسنده , , Hassen، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2003
Abstract :
The ethyl α-bromomethyl-β-(diethoxyphosphoryl)acrylic acid ester 9 has been prepared by addition of bromine to allylphosphonate 7 then dehydrobromination with DBU in acetonitrile. Reaction of allylic bromide 9 with primary amines in a bimolecular SN2′-type mecanism in methanol at low temperature, gives rise to the 2-[alkylamino(diethoxyphosphoryl)methyl]acrylic acid ethyl esters 6.
Keywords :
dimethyl ?-(bromomethyl)fumarate
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
