Title of article
Application of an immobilised amylose-based chiral stationary phase to the development of new monoamine oxidase B inhibitors
Author/Authors
Sanna، نويسنده , , Maria Luisa and Maccioni، نويسنده , , Elias and Vigo، نويسنده , , Sara and Faggi، نويسنده , , Cristina and Cirilli، نويسنده , , Roberto، نويسنده ,
Issue Information
ماهنامه با شماره پیاپی سال 2010
Pages
6
From page
426
To page
431
Abstract
A direct HPLC enantioseparation of three new chiral oxadiazoline derivatives endowed with potential MAO-B inhibitory activity was accomplished on the immobilised Chiralpak IA chiral stationary phase. Multi-mg amounts of enantiomers with high enantiomeric purity (ee ≥ 98%) were rapidly collected using pure dichloromethane as eluent. The absolute configuration and chiroptical properties of the enantiomers isolated at semipreparative scale were exhaustively determined.
Keywords
Chiroptical properties , MAO-inhibitors , absolute configuration , Enantioselective HPLC , Enantiomers , Chiralpak IA
Journal title
Talanta
Serial Year
2010
Journal title
Talanta
Record number
1660175
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