Author/Authors :
Beumer، نويسنده , , Raphael and Bayَn، نويسنده , , Pau and Bugada، نويسنده , , Piergiuliano and Ducki، نويسنده , , Sylvie and Mongelli، نويسنده , , Nicola and Sirtori، نويسنده , , Federico Riccardi and Telser، نويسنده , , Joachim and Gennari، نويسنده , , Cesare، نويسنده ,
Abstract :
The synthesis of a number of novel simplified eleutheside analogues with potent tubulin-assembling and microtubule-stabilizing properties is described, using ring-closing metathesis as the key-step for obtaining the 6–10 fused bicyclic ring system.
Keywords :
metathesis , stereocontrol , allylation , Antitumour compounds
