Synthesis of bifunctional P-chiral hydroxy phosphinates; lipase-catalyzed stereoselective acylation of ethyl (1-hydroxyalkyl)phenylphosphinates

Lipase-catalyzed acylation of ethyl (1-hydroxyalkyl)phenylphosphinates afforded a single diastereomer in high enantiomeric excess. The substituent effect of the alkyl group toward the acylation using Candida antractica (CAL) was larger than that of an immobilized lipase from Pseudomonas fluorescens lipase (lipase AK).