Title of article
A convenient strategy of dimerization by microwave heating and using 2,5-diketopiperazine as scaffold
Author/Authors
Santagada، نويسنده , , Vincenzo and Fiorino، نويسنده , , Ferdinando and Perissutti، نويسنده , , Elisa and Severino، نويسنده , , Beatrice and Terracciano، نويسنده , , Sara and Cirino، نويسنده , , Giuseppe and Caliendo، نويسنده , , Giuseppe، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2003
Pages
4
From page
1145
To page
1148
Abstract
A novel and convenient microwave-assisted dimerization of an active peptide compound using the DKPs as scaffold is described. The key reaction giving rise to the diketopiperazine scaffold is the intermolecular coupling. No epimerization was detected in the reactions used. Conventional and microwave heating of the reactions are compared. Synthesis by microwave irradiation gave the desired compounds in higher yields and in shorter reaction times than those obtained by conventional heating.
Keywords
synthesis of diketopiperazine , dimerization , microwave irradiation in solution
Journal title
Tetrahedron Letters
Serial Year
2003
Journal title
Tetrahedron Letters
Record number
1660485
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