Author/Authors :
Karam، نويسنده , , Omar and Zunino، نويسنده , , Fabien and Chagnaut، نويسنده , , Vincent and Jouannetaud، نويسنده , , Marie-Paule and Jacquesy، نويسنده , , Jean Claude، نويسنده ,
Abstract :
A four-step synthesis of 6-hydroxymelatonin 5, major human metabolite of melatonin 1, is reported starting from melatonin. The synthesis involves in the keys steps a regioselective Friedel–Crafts acylation followed by a Baeyer–Villiger oxidation. The overall yield is 48%.
