Title of article :
Synthesis and antitumor activity of DNA binding cationic porphyrin–platinum(II) complexes
Author/Authors :
Song، نويسنده , , Rita and Kim، نويسنده , , Yeong-Sang and Lee، نويسنده , , Chong Ock and Sohn، نويسنده , , Youn Soo، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2003
Abstract :
A new series of DNA binding 5,10,15-tri(N-methyl-4-pyridiniumyl)porphyrin (TrisMPyP)-platinum(II) conjugates was synthesized, in which different spacer ligands were used for appropriate coordination to platinum(II) complexes. Compound 9b exhibited in vivo antitumor activity (T/C%, 294) superior to cisplatin (T/C%, 184) against the leukemia L1210 cell line.
Keywords :
Porphyrin , Antitumor agent , Platinum(II) , DNA binding
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
