Author/Authors :
Sharp، نويسنده , , Thomas R. and Leeman، نويسنده , , Kyle R. and Bryant، نويسنده , , D.Eugene and Horan، نويسنده , , George J.، نويسنده ,
Abstract :
Photostability challenge of ziprasidone in solution shows that the benzisothiazole moiety undergoes isomerization to the corresponding benzthiazole. A model compound, 3-piperazinyl-1,2-benzisothiazole, also undergoes this photoisomerization. Identification of the products has been confirmed by synthesis of the proposed molecules.
