Author/Authors :
Bashford، نويسنده , , Katherine E. and Burton، نويسنده , , Matthew B. and Cameron، نويسنده , , Stuart and Cooper، نويسنده , , Anthony L. and Hogg، نويسنده , , Rebecca D. and Kane، نويسنده , , Peter D. and MacManus، نويسنده , , David A. and Matrunola، نويسنده , , Christopher A. and Moody، نويسنده , , Christopher J. and Robertson، نويسنده , , Avril A.B. and Warne، نويسنده , , Mark R.، نويسنده ,
Abstract :
The Bohlmann–Rahtz reaction has been used to prepare 2,3,6-trisubstituted pyridines suitable for use in library synthesis. The synthesis of piperidine substituted nicotinic acid derivative 9 has been optimised and carried out on a large scale to give ca. 500 g of scaffold which was used in the generation of the pyridine library 11.
