Author/Authors :
Belokon’، نويسنده , , Yuri N. and Bhave، نويسنده , , Devayani and DʹAddario، نويسنده , , Daniela and Groaz، نويسنده , , Elizabetta and Maleev، نويسنده , , Viktor and North، نويسنده , , Michael and Pertrosyan، نويسنده , , Armine، نويسنده ,
Abstract :
Copper(salen) complex 1 has been found to catalyse the asymmetric alkylation of enolates derived from a variety of amino acids. There is a clear relationship between the size of the side chain in the substrate and the enantioselectivity of the process, so that the enantioselectivity decreases in the order alanine>aminobutyric acid>allylglycine>leucine>phenylalanine>valine. A transition state model which accounts for the influence of the size of the side chain on the enantioselectivity of the reactions is presented.
Keywords :
Enolate alkylation , Asymmetric catalysis , copper(salen) complex , ? , ?-disubstituted amino acid
