Title of article
Catalytic, asymmetric synthesis of α,α-disubstituted amino acids
Author/Authors
Belokon’، نويسنده , , Yuri N. and Bhave، نويسنده , , Devayani and DʹAddario، نويسنده , , Daniela and Groaz، نويسنده , , Elizabetta and Maleev، نويسنده , , Viktor and North، نويسنده , , Michael and Pertrosyan، نويسنده , , Armine، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2003
Pages
4
From page
2045
To page
2048
Abstract
Copper(salen) complex 1 has been found to catalyse the asymmetric alkylation of enolates derived from a variety of amino acids. There is a clear relationship between the size of the side chain in the substrate and the enantioselectivity of the process, so that the enantioselectivity decreases in the order alanine>aminobutyric acid>allylglycine>leucine>phenylalanine>valine. A transition state model which accounts for the influence of the size of the side chain on the enantioselectivity of the reactions is presented.
Keywords
Enolate alkylation , Asymmetric catalysis , copper(salen) complex , ? , ?-disubstituted amino acid
Journal title
Tetrahedron Letters
Serial Year
2003
Journal title
Tetrahedron Letters
Record number
1661009
Link To Document