Author/Authors :
Zhang، نويسنده , , Wei and Chen، نويسنده , , Christine Hiu-Tung and Nagashima، نويسنده , , Tadamichi، نويسنده ,
Abstract :
A fluorous isatoic anhydride and isocyanate are synthesized and used as scavengers for amines in solution-phase parallel synthesis of urea, thiourea, and β-hydroxyamine analogs. The resulting fluorous derivatives are readily separated from the reaction mixture by solid-phase extractions (SPE) over FluoroFlash™ cartridges to give products with good purity. The SPE cartridges can be reused.
