Title of article :
The first example of a preparative 1,4-perfluoroalkylation using (perfluoroalkyl)trimethylsilanes
Author/Authors :
Sosnovskikh، نويسنده , , V.Ya and Sevenard، نويسنده , , D.V and Usachev، نويسنده , , B.I and Rِschenthaler، نويسنده , , G.-V، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2003
Abstract :
Reactions of 2-perfluoroalkylchromones with (perfluoroalkyl)trimethylsilanes proceed as a 1,4-nucleophilic perfluoroalkylation to give 2,2-bis(perfluoroalkyl)chroman-4-ones in high yields after acid hydrolysis. Oxidation of 2,2-bis(trifluoromethyl)-6-methylchroman-4-one with K2S2O8 leads to fluorinated analogs of natural lactarochromal and the corresponding acid.
Keywords :
2 , (perfluoroalkyl)trimethylsilanes , 2-bis(perfluoroalkyl)chroman-4-ones , trifluoromethylated analogues of natural lactarochromal and corresponding acids , 2-perfluoroalkylchromones
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
