Title of article :
Facile N-1 protection of cyclam, cyclen and 1,4,7-triazacyclononane
Author/Authors :
Yang، نويسنده , , Wen and Giandomenico، نويسنده , , Christen M. and Sartori، نويسنده , , Michael and Moore، نويسنده , , Dennis A.، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2003
Abstract :
An exceptionally high yielding method for the tri-protection of cyclam and cyclen using ethyl trifluoroacetate is described. The selective reaction also applies to the di-protection of 1,4,7-triazacyclononane. The application of this method in the synthesis of AMD3100, a clinical candidate for stem cell mobilization is presented.
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
