Author/Authors :
Xu، نويسنده , , Lianhong and Zhang، نويسنده , , Lijun and Bryant، نويسنده , , Clifford M. and Kim، نويسنده , , Choung U. Kim، نويسنده ,
Abstract :
AN1057A/B has shown potent activity against MRSA. A novel and concise route to the synthesis of its heterocycle core 2,5-diamino-5,6-dihydro-1H-pyrimidine-4-one is described. This methodology allows the synthesis of an array of analogs with different amine substitutions at the 2-position.
