Title of article
The total synthesis of (−)-tetrahydrolipstatin
Author/Authors
Bodkin، نويسنده , , Jennifer A and Humphries، نويسنده , , Edward J and McLeod، نويسنده , , Malcolm D، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2003
Pages
4
From page
2869
To page
2872
Abstract
Careful control during the bromolactonisation of β,γ-unsaturated acid 3 was required to afford regioselectively the trans-β-lactone 4 as the major diastereomer. Radical debromination of 4 followed by a three-step sequence of reactions afforded the lipase inhibitor (−)-tetrahydrolipstatin.
Keywords
(?)-tetrahydrolipstatin , bromolactonisation , radical dehalogenation , ?-Lactone
Journal title
Tetrahedron Letters
Serial Year
2003
Journal title
Tetrahedron Letters
Record number
1661521
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