Title of article
Chemoselective peptide bond formation using formyl-substituted nitrophenylthio ester
Author/Authors
Ishiwata، نويسنده , , Akihiro and Ichiyanagi، نويسنده , , Tsuyoshi and Takatani، نويسنده , , Maki and Ito، نويسنده , , Yukishige، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2003
Pages
4
From page
3187
To page
3190
Abstract
A novel method for peptide bond formation utilizing amino acid 2-formyl-4-nitrophenylthio ester has been developed. The reaction can be performed in water-containing media and is compatible with various types of amino acid side-chain functional groups. Use of N-methylmaleinimide as an additive is essential for the reaction to proceed with high efficiency. It captures liberated formyl-substituted thiophenol through 1,4-addition followed by aldol cyclization.
Journal title
Tetrahedron Letters
Serial Year
2003
Journal title
Tetrahedron Letters
Record number
1661706
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