Author/Authors :
Tisdale، نويسنده , , Eric J. and Kochman، نويسنده , , David A. and Theodorakis، نويسنده , , Emmanuel A.، نويسنده ,
Abstract :
A total synthesis of atroviridin (1) based on biosynthetic principles is presented. The tetracyclic xanthone structure of the natural product was constructed by coupling aryl bromide 8 with aldehyde 7 and subsequent intramolecular conjugate addition on a quinone precursor. Bromide 8 was produced from aldehyde 9 via a sequence of steps involving Baeyer–Villiger oxidation and Claisen cyclization.
