Author/Authors :
Harriman، نويسنده , , Geraldine C.B and Chi، نويسنده , , Shannon and Zhang، نويسنده , , Min and Crowe، نويسنده , , Andrea and Bennett، نويسنده , , Robert W. and Parsons، نويسنده , , Ian، نويسنده ,
Abstract :
The synthesis of the biologically relevant, 4-trifluoromethylpyrido[1,2-a]pyrimidin-2-one 7, is reported. Addition of substituted 2-aminopyridines 5 to activated alkynoates leads to the facile formation of a series of metabolically stable trifluoromethyl substituted pyrido[1,2-a]pyrimidines under mild conditions.
