Author/Authors :
Suzuki، نويسنده , , Tatsuo and Inui، نويسنده , , Masaharu and Hosokawa، نويسنده , , Seijiro and Kobayashi، نويسنده , , Susumu، نويسنده ,
Abstract :
Ketene N,O-acetals were prepared stereoselectively and submitted to a Lewis acid-mediated 1,3-rearrangement to afford C-alkylated products. The reactions proceeded in a stereoselective manner to construct a chiral quaternary carbon in high selectivity. The stereochemistry of the quaternary center was found to be opposite to that obtained by an anionic direct dienolate alkylation.
