Author/Authors :
Congreve، نويسنده , , Miles S. and Kay، نويسنده , , Corinne and Scicinski، نويسنده , , Jan J. and Ley، نويسنده , , Steven V. and Williams، نويسنده , , Geoffrey and Murray، نويسنده , , Peter J. and McKeown، نويسنده , , Stephen C. and Watson، نويسنده , , Stephen P.، نويسنده ,
Abstract :
The development of a versatile amine releasing linker based on the modified o-nitrobenzene sulfonamide protective group is described. This new N-Boc-o-nitrobenzenesulfonamide (Boc-ONBS) linker enables the elaboration on resin of primary and secondary amines by sequential substitution of the sulfonamide moiety using the Mitsunobu reaction. A 16-member array of secondary and Boc protected primary amines was then prepared using this linker.
