Guanacastepene-A total synthesis: construction of the tricyclic iso-guanacastepane, epi-guanacastepane and guanacastepane frameworks

Studies aimed towards the total synthesis of the diterpene antibiotic, guanacastepene A, of current interest and displaying promising biological activity against drug resistant pathogens has led to the generation of some novel tricyclic skeleta replete with extensive functionalization and representing interesting variations of the guanacastepane framework.