Author/Authors :
Merschaert، نويسنده , , Alain and Delhaye، نويسنده , , Laurent and Kestemont، نويسنده , , Jean-Paul and Brione، نويسنده , , Willy and Delbeke، نويسنده , , Pieter and Mancuso، نويسنده , , Vincent and Napora، نويسنده , , Freddy and Diker، نويسنده , , Khalid and Giraud، نويسنده , , Daniel and Vanmarsenille، نويسنده , , Michel، نويسنده ,
Abstract :
A stereoselective approach has been developed for the synthesis of cis- and trans-2-methyl-4-arylpiperidines from a common intermediate. The Ni-catalyzed hydrogenolysis of N-Boc-2-methyl-4-aryl-4-piperidinols, obtained by addition of organometallic reagents on N-Boc-2-methyl-4-piperidone, afforded the trans derivatives with up to 95% selectivity whereas the corresponding cis isomers were obtained in the presence of palladium catalysts.
Keywords :
nickel , piperidines , PALLADIUM , Hydrogenolysis
