Title of article
Chiral diaminophosphine ligands with stable C(aryl)N(amine) axial chirality derived from prolinol
Author/Authors
Mino، نويسنده , , Takashi and Tanaka، نويسنده , , Youichi and Sato، نويسنده , , Yutaka and Saito، نويسنده , , Akio and Sakamoto، نويسنده , , Masami and Fujita، نويسنده , , Tsutomu، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2003
Pages
3
From page
4677
To page
4679
Abstract
New type chiral ligands 3, which have a chiral carbon center and stable C(aryl)-N(amine) axial chirality, were prepared from chiral prolinol-derived aminophosphine oxide 4. Pd-catalyzed asymmetric allylic alkylation of 1,3-diphenyl-2-propenyl acetate (6) with a dimethyl malonate–BSA–LiOAc system was successfully carried out in the presence of 3d resulting in a good yield with good enantioselectivity (up to 95% ee).
Keywords
C?N axial chirality , PALLADIUM , P , asymmetric allylic alkylation , N-ligand
Journal title
Tetrahedron Letters
Serial Year
2003
Journal title
Tetrahedron Letters
Record number
1662581
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