Title of article
A facile synthesis of 3-aryl pyroglutamic acid. Facile synthesis of baclofen and chlorpheg
Author/Authors
Chang، نويسنده , , Meng-Yang and Sun، نويسنده , , Peipei and Chen، نويسنده , , Shui-Tein and Chang، نويسنده , , Nein-Chen Chang، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2003
Pages
3
From page
5271
To page
5273
Abstract
A facile synthesis of 3-aryl pyroglutamic acids via stepwise [3+2] annulation and desulfonated hydrolysis is reported. Base-induced coupling/cyclization reactions of α-sulfonylacetamide with various β-functional groups of (Z)-2-bromoacrylates yielded three contiguous chiral centers on the polysubstituted pyroglutamates system with trans–trans orientation in a one-pot synthesis. This facile strategy was used to synthesize amino acid derivatives baclofen and chlorpheg.
Keywords
chlorpheg , Baclofen , glutarimides , pyroglutamic acid
Journal title
Tetrahedron Letters
Serial Year
2003
Journal title
Tetrahedron Letters
Record number
1662946
Link To Document