Title of article :
1,3-Cycloaddition of nitrile oxides in ionic liquids. An easier route to 3-carboxy isoxazolines, potential constrained glutamic acid analogues
Author/Authors :
Conti، نويسنده , , Dario and Rodriquez، نويسنده , , Manuela and Sega، نويسنده , , Alessandro and Taddei، نويسنده , , Maurizio، نويسنده ,
Abstract :
Several improvements in the cycloaddition of carboethoxyformonitrile oxide (CEFNO) with different alkenes are observed in the ionic liquids [bmim][BF4] and [bmim][PF6]. The possibility of obtaining good yields of the corresponding isoxazolines opens the way towards parallel collections of glutamic acid (Glu) analogues.
