Determination of tricyclic antidepressants using a carbon paste electrode modified with β-cyclodextrin

Carbon paste electrodes modified with β-cyclodextrin have been investigated for the DP voltammetric determination of the tricyclic antidepressants – imipramine, trimipramine and thioridazine. Host–guest interaction was studied and experimental conditions of the working procedure were optimized. The accumulation ability of β-cyclodextrin leads to detection limits down to nanomolar concentrations for 120 s accumulation. The electrode was applied to the determination of imipramine and thioridazine in pharmaceuticals.