Author/Authors :
Yang، نويسنده , , Le-Le and Liu، نويسنده , , Xiuming and Liu، نويسنده , , Kun and Liu، نويسنده , , Huan and Zhao، نويسنده , , Fang-Yao and Ruan، نويسنده , , Wen-juan and Li، نويسنده , , Yue and Chang، نويسنده , , Ze and Bu، نويسنده , , Xian-He، نويسنده ,
Abstract :
By retaining the quadrapyridyl receptor of polypyridylhexaazatriphenylene (a Cd2+ sensor reported by us) and extending its chromophoric group with pyrene, a chemical sensor (1) was designed and synthesized in this work. This sensor exhibit selective off-on fluorescence response to Cd2+ over other metal ions, and the detection limit is as low as 0.02 μM. The Cd2+ sensing of 1 has high water toleration and can be carried out in the media with the water content up to 70%. Additionally, 1 was successfully applied to the in vivo imaging of intracellular Cd2+ in living HaLa cells, and showed low cytotoxicity and cell membrane permeability in these experiments. These results suggest that 1 has potential application in the Cd2+ analysis of environmental and biological samples.
Keywords :
Cd2+ ion , fluorescent sensor , Quadrapyridyl type receptor , Water toleration , cell imaging
