Influence of material properties on the agglomeration of water-soluble amorphous particles

The viscosity and elasticity of particles influence their agglomeration behaviour. Such mechanical particle properties are determined by the supra-molecular and microscopic structure of the particles and process conditions such as temperature, humidity and strain rate or frequency. ood powders are composed of amorphous water soluble substances. Accordingly spray dried dextrose syrup is used as a model substance for the current study. morphous water-soluble substances show visco-elastic behaviour and depending on strain rate, temperature and moisture content, either the viscous or the elastic properties dominate their material behaviour. The viscous behaviour of a material can be characterised through its shear or its complex viscosity. The materials viscosity affects all types of agglomeration processes. The complex viscosity can be measured by Dynamic Mechanical Thermal Analysis (DMTA) while the shear viscosity is typically determined using a rotational viscometer. Alternatively it is possible to estimate the viscosity based on the difference between glass transition and process temperature. current study the glass transition temperature of spray dried dextrose syrup (DE21) is measured for different moisture contents and the obtained data are used for estimating the viscosity. In addition, the viscosity of the dextrose syrup powder at different temperature/moisture/frequency combinations is determined for higher viscosities by DMTA or measured for the lower viscosity range using a rotational viscometer. The obtained data are used to predict growth and pressure agglomeration processes such as fluid bed agglomeration and tabletting.