Title of article
Solubility of fractal nanoparticles
Author/Authors
Albert Mihranyan، نويسنده , , Albert and Strّmme، نويسنده , , Maria، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2007
Pages
5
From page
315
To page
319
Abstract
A relationship between the fractal surface dimension of dissolving nanoparticles and their solubility has been derived showing that fractally rough nanoparticles are expected to exhibit significantly higher solubility than predicted from the classical Ostwald–Freundlich equation. The derived relationship estimates the latent solubility increase for a given material by manipulating the surface of the particles to be dissolved, and can thus be used for developing new strategies for improving the solubility of poorly soluble drug candidates.
Keywords
Dissolution , solubility , Ostwald–Freundlich equation , Nanoparticles , Fractal surface dimension
Journal title
Surface Science
Serial Year
2007
Journal title
Surface Science
Record number
1700076
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