Title of article
Determination of fluvastatin and its five metabolites in human plasma using simple gradient reversed-phase high-performance liquid chromatography with ultraviolet detection
Author/Authors
Nakashima، نويسنده , , Akinori and Saxer، نويسنده , , Christoph and Niina، نويسنده , , Miyuki and Masuda، نويسنده , , Naoki and Iwasaki، نويسنده , , Kazuhide and Furukawa، نويسنده , , Kotaro، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2001
Pages
9
From page
17
To page
25
Abstract
A simple gradient reversed-phase high-performance chromatographic method with ultraviolet detection for the determination of fluvastatin (FV) and its five metabolites, (M-2, M-3, M-4, M-5 and M-7) in human plasma was developed and validated. The limit of quantification of FV and its five metabolites in human plasma was 10 ng ml−1. The assay had satisfactory selectivity, recovery, linearity and precision accuracy. Stability studies showed that FV and its five metabolites were stable in plasma up to at least 1 month of storage at −30°C.
Keywords
Fluvastatin , HMG CoA reductase
Journal title
Journal of Chromatography B Biomedical Sciences and Applications
Serial Year
2001
Journal title
Journal of Chromatography B Biomedical Sciences and Applications
Record number
1705580
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