Title of article :
Total synthesis of (−)-(8R, 10S)- and (+)-(8S, 10R)-8-hydroxypolypoda-13,17,21-triene based on enzymatic resolution
Author/Authors :
Kinoshita، نويسنده , , Masako and Nakamura، نويسنده , , Daisuke and Fujiwara، نويسنده , , Naoko and Akita، نويسنده , , Hiroyuki، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2003
Abstract :
The total synthesis of (−)-(8R, 10S)- and (+)-(8S, 10R)-8-hydroxypolypoda-13,17,21-triene (1) was achieved based on the kinetic resolution of (±)-epoxy-albicanol (3) using lipase. The absolute structure of natural product (1) was synthetically again confirmed to be (5S, 8R, 9R, 10S)-8-hydroxypolypoda-13,17,21-triene.
Keywords :
Lipase , Candida rugosa , Enantioselective acetylation , total synthesis , enzymatic resolution
Journal title :
Journal of Molecular Catalysis B Enzymatic
Journal title :
Journal of Molecular Catalysis B Enzymatic
