Lactones 20 : Biohydroxylation of saturated bicyclic γ-lactones with the substituted cyclohexane system

Three bicyclic saturated γ-lactones with various numbers of methyl groups at the cyclohexane ring were transformed into the corresponding hydroxylactones. The most effective biohydroxylations were performed by means of cultures Fusarium culmorum and Absidia cylindrospora. Biotransformations of lactones 4a and b afforded the hydroxylactones with the secondary hydroxy groups (5a and b), whereas the hydroxy group introduced into the lactone 4c turned out to be tertiary giving the product 5c.