Title of article
Asymmetric synthesis of arylselenoalcohols by means of the reduction of organoseleno acetophenones by whole fungal cells
Author/Authors
Andrade، نويسنده , , Leandro H. and Omori، نويسنده , , ءlvaro T. and Porto، نويسنده , , André L.M. and Comasseto، نويسنده , , Joمo V.، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2004
Pages
8
From page
47
To page
54
Abstract
A series of novel organoseleno acetophenones (3a–f) have been synthesized. The microbial reduction of the seleno ketones (3) has been evaluated using whole cells of Rhizopus oryzae CCT 4964, Aspergillus terreus CCT 3320, A. terreus CCT 4083 and Emericella nidulans CCT 3119. These microorganisms showed Prelog and anti-Prelog stereoselectivity, leading to the arylselenoalcohols in moderate to high enantiomeric excesses. The organoselenium compounds were compatible with the biocatalytic conditions employed.
Keywords
microbial reduction , Whole fungal cells , Selenium , alcohols , ketones
Journal title
Journal of Molecular Catalysis B Enzymatic
Serial Year
2004
Journal title
Journal of Molecular Catalysis B Enzymatic
Record number
1710176
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