Title of article :
Regioselective enzymatic acylation of N-acetylhexosamines
Author/Authors :
Pavla Simerska، نويسنده , , Pavla and Pi?vejcov?، نويسنده , , Andrea and Kuzma، نويسنده , , Marek and Sedmera، نويسنده , , Petr and K?en، نويسنده , , Vladim??r and Nicotra، نويسنده , , Silvia and Riva، نويسنده , , Sergio، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2004
Abstract :
A careful choice of the reaction conditions (solvent, enzyme, acylating agent) allowed an efficient regioselective acylation of N-acetylhexosamines. 6-O-Acyl derivatives of 2-acetamido-2-deoxy-d-glucopyranose (GlcNAc), 2-acetamido-2-deoxy-d-galactopyranose (GalNAc) and 2-acetamido-2-deoxy-d-mannopyranose (ManNAc) have been isolated from regioselective esterifications catalysed by the protease subtilisin in CH3CN–DMSO 8:2 in good yields.
Keywords :
N-Acetylhexosamines , regioselectivity , Enzymatic acylation , SUBTILISIN , DMSO
Journal title :
Journal of Molecular Catalysis B Enzymatic
Journal title :
Journal of Molecular Catalysis B Enzymatic
