Title of article
Microbiological production of omeprazole metabolites by Cunninghamella elegans
Author/Authors
Pearce، نويسنده , , Clive M. and Lushnikova، نويسنده , , Marina V.، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
5
From page
87
To page
91
Abstract
Incubation of Cunninghamella elegans ATCC 9245 and the anti ulcer drug omeprazole allowed putative fungal metabolites to be isolated in sufficient quantities for structural elucidation. Three metabolites produced by the fungi were isolated using semi-preparative HPLC and their structures identified by a combination of LC/MS(n) and NMR experiments. These isolates will be used as reference standards in the confirmatory analysis of mammalian metabolites of this drug.
Keywords
NMR , Cunninghamella elegans , Omeprazole , Reduction , metabolites
Journal title
Journal of Molecular Catalysis B Enzymatic
Serial Year
2006
Journal title
Journal of Molecular Catalysis B Enzymatic
Record number
1711018
Link To Document