Amphiphilic antidepressant drug amitriptyline hydrochloride under the influence of ionic and nonionic hydrotropes; micellization and phase separation

Herein we report the micellization and cloud point of an amitriptyline hydrochloride (AMT) under the influence of cationic, anionic and nonionic hydrotropes. Anionic hydrotropes were employed to know the micellar and surface behaviors, besides studying the clouding behavior of AMT drug with cationic, anionic and nonionic hydrotropes. Tensiometric study has been performed and the properties studied include the critical micelle concentration (cmc), maximum surface excess at the air/water interface (Γmax), the minimum area per of amphiphilic molecule at air/water interface (Amin), and the different thermodynamic parameters, besides clouding phenomenon. Interaction parameters of micelles (βm) and monolayer (βσ) indicate that drug-hydrotrope systems show better interaction at the interface than in micelles.