Investigation of micellar and phase separation phenomenon of phenothiazine drug promazine hydrochloride with anionic hydrotropes

The purpose of the present study was to determine the influence of various anionic hydrotropes on the self-aggregation and phase behavior of amphiphilic drug promazine hydrochloride (PMZ) and to search for means which reduce/increase the values of critical micelle concentration (cmc) and boost/suppress the cloud point (CP), respectively, used in pharmaceutical formulations. By using regular solution theory (RST) and Rosenʹs model various micellar and surface properties such as micellar composition, surface excess concentration (Γmax), interaction parameters (βm, βσ) etc. have been determined. The solution micellar behaviors were also investigated using Motomura and Rodenas models for defense and comparison of results. Thermodynamic parameters were also evaluated and discussed.