Lipase-catalysed resolution of N-(3-cyano-2-hydroxy propan-1-yl)phthalimide: Synthesis of (R)-GABOB and (R)-carnitine

The lipase-mediated resolution of N-(3-cyano-2-hydroxy propan-1-yl)phthalimide using various lipases in different solvents has been studied and this intermediate was utilized towards the synthesis of enantiomerically enriched (R)-GABOB and (R)-carnitine in high yields.