Title of article
Microbial transformation of dehydroandrographolide by Cunninghamella echinulata
Author/Authors
Xin، نويسنده , , Xiu-lan and Su، نويسنده , , Donghai and Wang، نويسنده , , Xiao-jie and Yuan، نويسنده , , Qi-peng، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2009
Pages
5
From page
201
To page
205
Abstract
The capabilities of 24 strains of filamentous fungi (from 11 genera) to transform dehydroandrographolide (1) were screened. The highly region-specific hydroxylation of 1 at C-9 by Cunninghamella echinulata AS 3.3400 was observed. Five products were obtained, and they were identified as 9β-hydroxydehydroandrographolide (2), 3-oxo-hydroxydehydroandrographolide (3), 3-oxo-9β-hydroxydehydroandrographolide (4), 7α-hydroxydehydroandrographolide (5) and 8β,17α-epoxydehydroandrographolide (6), respectively. Among them, products 2, 4 and 5 were novel compounds.
Keywords
Dehydroandrographolide , Microbial transformation , Cunninghamella echinulata , hydroxylation , Diterpenoids
Journal title
Journal of Molecular Catalysis B Enzymatic
Serial Year
2009
Journal title
Journal of Molecular Catalysis B Enzymatic
Record number
1713995
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