Title of article
Biocatalyzed irreversible esterification in the preparation of S-naproxen
Author/Authors
Morrone، نويسنده , , R. and D’Antona، نويسنده , , N. and Lambusta، نويسنده , , D. and Nicolosi، نويسنده , , G.، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2010
Pages
3
From page
49
To page
51
Abstract
Dimethyl carbonate was used as alcohol donor in the esterification of naproxen in the presence of immobilised lipase B from Candida antarctica (Novozym 435). The conjugation of hydrolysis of dimethyl carbonate and esterification of acid, created irreversible operative conditions so permitting the recovery of S-naproxen in high ee (>98%). The adopted procedure has a general use.
Keywords
Naproxen , NSAID , Lipase , Dimethyl carbonate , Profen , Irreversible esterification
Journal title
Journal of Molecular Catalysis B Enzymatic
Serial Year
2010
Journal title
Journal of Molecular Catalysis B Enzymatic
Record number
1714612
Link To Document