Title of article
Microbial oxidation and glucosidation of echinocystic acid by Nocardia corallina
Author/Authors
Feng، نويسنده , , Xu and Zou، نويسنده , , Zhongmei and Fu، نويسنده , , Shaobin and Sun، نويسنده , , Lingzhi and Su، نويسنده , , Zhiheng and Sun، نويسنده , , Di-An، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2010
Pages
5
From page
219
To page
223
Abstract
Echinocystic acid (3β,16α-dihydroxy-olean-12-en-28-oic acid 1) is a complex compound with many bioactivities. Microbial transformation of echinocystic acid (1) by Nocardia corallina CGMCC4.1037 has been studied. Incubation of echinocystic acid with N. corallina CGMCC4.1037 afforded three metabolites: 3-oxo-16α-hydroxy-olean-12-en-28-oic acid (2), 3β,16α-dihydroxy-olean-12-en-28-oic acid 28-O-β-d-glucopyranoside (3), and 3-oxo-16α-hydroxy-olean-12-en-28-oic acid 28-O-β-d-glucopyranoside (4). Product (4) was a new product. Their structure elucidation was mainly based on the HRMS and NMR data. The possible mechanism of the regio-selective oxidation of the 3-OH and a probable sequence of these transformations were also discussed. This is the first report on the microbial transformation of echinocystic acid (1). This method may open a new route to the future modification of echinocystic acid (1).
Keywords
Nocardia corallina CGMCC4.1037 , biotransformation , Microbial transformation , Echinocystic acid , Glucosidation , Hydroxy oxidation
Journal title
Journal of Molecular Catalysis B Enzymatic
Serial Year
2010
Journal title
Journal of Molecular Catalysis B Enzymatic
Record number
1714765
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