Lactones 13: Biotransformation of iodolactones

Several fungal strains were screened for their ability to transform iodolactones. The most efficient was a culture of Botrytis cinerea. This microorganism transformed δ-iodo-γ-lactone (3) into two products: hydroxy iodolactone (5) and hydroxy unsaturated lactone (6). The biotransformation of γ-iodo-δ-lactone (4) afforded only one product, the hydroxy iodolactone (7).